Dipeptidil peptidaza 4

Dipeptidil peptidaza 4 (DPP4) ili CD26 je protein koji kod čovjeka kodiran genom DPP4.^[1]

Protein kodiran genom DPP4 je antigeni enzim izražena na većini vrsta stanica i povezuje se sa imunoregulacijom, transdukcijom signala i apoptozom. To je intrinzični membranski glikoprotein i serin egzopeptidaza koja cijepa x-prolin dipeptide sa N-terminalnih dijelova polipeptida. Enzim dipeptidil peptidaza 4 ima dosada poznata najmanje 62 substrata, među koje se ubrajaju faktori rasta, kemokini, neuropeptidi i vazoaktivni peptidi.^[2]

DPP4 ima važu ulogu u metabolizmu glukoze, inaktivirajući inkretine, što je rezultiralo stvaranjem nove skupine antidijabetika - inhibitori dipeptidil peptidaze 4.

Prema nekim istraživanjima DPP4 djeluje kao supresor u razvoju tumora.^[3]^[4]^[5] DPP4/CD26 ima važnu ulogu u biologiji tumor, i može poslužiti kao tumorski marker različitih vrsta tumora, zato što je kod nekih vrsta tumora vrijednost povišena, a kod nekih snižena.

Reference

↑ Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C (srpnja 1993). "Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science (journal) 261 (5120): 466–9. PMID 8101391. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8101391
↑ Chen X (2006). "Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8". Adv. Exp. Med. Biol. 575: 27–32. doi:10.1007/0-387-32824-6_3. PMID 16700505
↑ Pro B, Dang N (2004). "CD26/dipeptidyl peptidase IV and its role in cancer". Histol Histopathol 19 (4): 1345–51. PMID 15375776
↑ Masur K et al. (2006). "DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells". Regul Pept. 137 (3): 147–55. doi:10.1016/j.regpep.2006.07.003. PMID 16908079
↑ Wesley UV et al. (2005). "Dipeptidyl peptidase inhibits malignant phenotype of prostate cancer cells by blocking basic fibroblast growth factor signaling pathway". Cancer Res. 65 (4): 1325–34. doi:10.1158/0008-5472.CAN-04-1852. PMID 15735018

[pmid8101391-1] Kameoka J, Tanaka T, Nojima Y, Schlossman SF, Morimoto C (srpnja 1993). "Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science (journal) 261 (5120): 466–9. PMID 8101391. http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=8101391

[pmid16700505-2] Chen X (2006). "Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8". Adv. Exp. Med. Biol. 575: 27–32. doi:10.1007/0-387-32824-6_3. PMID 16700505

[3] Pro B, Dang N (2004). "CD26/dipeptidyl peptidase IV and its role in cancer". Histol Histopathol 19 (4): 1345–51. PMID 15375776

[4] Masur K et al. (2006). "DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells". Regul Pept. 137 (3): 147–55. doi:10.1016/j.regpep.2006.07.003. PMID 16908079

[5] Wesley UV et al. (2005). "Dipeptidyl peptidase inhibits malignant phenotype of prostate cancer cells by blocking basic fibroblast growth factor signaling pathway". Cancer Res. 65 (4): 1325–34. doi:10.1158/0008-5472.CAN-04-1852. PMID 15735018

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