VOC-202012/01: razlika između inačica

Posljednja izmjena od 2. siječanj 2022. u 13:08

Varijanta zabrinutosti 202012/01 (VOC-202012/01),^[1] prethodno poznata kao prva varijanta u istrazi u prosincu 2020. (VUI - 202012/01), a također i kao linija B. 1.1.7,^[2] inačica je SARS-CoV-2, virusa koji uzrokuje koronavirusnu bolest 2019. (COVID-19).^[3] Ova je varijanta prvi put otkrivena u listopadu 2020. godine tijekom pandemije COVID-19 u Ujedinjenom Kraljevstvu na uzorku uzetom prethodnog mjeseca,^[4] i brzo se počela širiti do sredine prosinca. Koreliran je sa značajnim porastom stope infekcije COVID-19 u Ujedinjenom Kraljevstvu; Smatra se da je ovo povećanje barem djelomično zbog promjene N501Y unutar domene vezivanja za receptor glikoproteina, koja je potrebna za vezanje na ACE2 u ljudskim stanicama.

Otkriće

Nova varijanta otkrivena je početkom prosinca 2020. godine, kombinirajući podatke o genomu sa znanjem da stope zaraze u Kentu ne padaju unatoč nacionalnim ograničenjima.

Dva najranija genoma koja pripadaju liniji B.1.1.7 prikupljena su 20. rujna 2020. u Kentu i još jedan 21. rujna 2020. u Londonu.^[5] Te su sekvence predane u bazu podataka GISAID sekvenci (pristupi sekvenci EPI_ISL_601443 i EPI_ISL_581117). Od 15. prosinca u liniji B.1.1.7 bilo je 1623 genoma. Od njih je 519 uzorkovano u širem Londonu, 555 u Kentu, 545 u drugim regijama Velike Britanije, uključujući Škotsku i Wales, te 4 u drugim zemljama.^[5]

Traganje unatrag pomoću genetskih dokaza sugerira da se ova nova varijanta pojavila u rujnu 2020. godine, a zatim je kružila na vrlo niskim razinama u populaciji do sredine studenog. Porast slučajeva povezanih s novom varijantom prvi je put izašao na vidjelo krajem studenoga kada je Public Health England (PHE) istraživao zašto stopa infekcije u Kentu nije pala usprkos nacionalnim ograničenjima. PHE je tada otkrio nakupinu povezanu s ovom varijantom koja se brzo širila u London i Essex.

Iako je varijanta prvi put otkrivena u Kentu, možda se nikada neće znati odakle je nastala. Otkriće u Velikoj Britaniji može samo odraziti da Velika Britanija radi više redoslijeda od mnogih drugih zemalja. Pretpostavlja se da varijanta možda potječe od kronično zaražene osobe s oslabljenim imunitetom, što daje virusu dugo vremena da se replicira i razvija.^[6]

Vidi još

Izvori

↑ "PHE investigating a novel strain of COVID-19". Public Health England. 14. prosinac 2020.. https://www.gov.uk/government/news/phe-investigating-a-novel-strain-of-covid-19
↑ Kupferschmidt, Kai (20. prosinac 2020.). "Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear" (engl.). https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear Pristupljeno 21. prosinac 2020.
↑ Zimmer, Carel; Carey, Benedict (21. prosinac 2020.). "The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here’s what scientists know.". The New York Times. https://www.nytimes.com/2020/12/21/health/new-covid-strain-uk.html Pristupljeno 23. prosinac 2020.
↑ "Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK". 20. prosinac 2020.. https://www.bbc.co.uk/news/world-europe-55385768
↑ ^5,0 ^5,1 Rambaut, Andrew; Loman, Nick; Pybus, Oliver; Barclay, Wendy; Barrett, Jeff; Carabelli, Alesandro; Connor, Tom; Peacock, Tom; L. Robertson, David; Vol, Erik (2020.). "Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations". Written on behalf of COVID-19 Genomics Consortium UK. https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 Pristupljeno 20. prosinac 2020.
↑ "New coronavirus variant: What do we know?". BBC. https://www.bbc.co.uk/news/health-55388846 Pristupljeno 22. prosinac 2020.

[1] "PHE investigating a novel strain of COVID-19". Public Health England. 14. prosinac 2020.. https://www.gov.uk/government/news/phe-investigating-a-novel-strain-of-covid-19

[Science_Mag-2] Kupferschmidt, Kai (20. prosinac 2020.). "Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear" (engl.). https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear Pristupljeno 21. prosinac 2020.

[NYT-20201221-3] Zimmer, Carel; Carey, Benedict (21. prosinac 2020.). "The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here’s what scientists know.". The New York Times. https://www.nytimes.com/2020/12/21/health/new-covid-strain-uk.html Pristupljeno 23. prosinac 2020.

[BBC-4] "Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK". 20. prosinac 2020.. https://www.bbc.co.uk/news/world-europe-55385768

[Rambaut_et_al-5] 5,0 ^5,1 Rambaut, Andrew; Loman, Nick; Pybus, Oliver; Barclay, Wendy; Barrett, Jeff; Carabelli, Alesandro; Connor, Tom; Peacock, Tom; L. Robertson, David; Vol, Erik (2020.). "Preliminary genomic characterisation of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations". Written on behalf of COVID-19 Genomics Consortium UK. https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 Pristupljeno 20. prosinac 2020.

[6] "New coronavirus variant: What do we know?". BBC. https://www.bbc.co.uk/news/health-55388846 Pristupljeno 22. prosinac 2020.

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@@ Redak 1: / Redak 1: @@
 <!--'''VOC-202012/01'''-->[[Datoteka:202012 01 Outbreak World Map.png|mini|Potvrđeni slučajevi VOC-202012/01 u svijetu (29. prosinca 2020.)]]
-'''Varijanta zabrinutosti 202012/01''' ('''VOC-202012/01'''),<ref>{{Cite web |title=PHE investigating a novel strain of COVID-19 |author= |publisher=Public Health England |date=14 December 2020 |url= https://www.gov.uk/government/news/phe-investigating-a-novel-strain-of-covid-19}}</ref> prethodno poznata kao prva varijanta u istrazi u prosincu 2020. (''VUI - 202012/01''), a također i kao linija ''B. 1.1.7'',<ref name="Science Mag">{{Cite web |ref={{sfnref|Kupferschmidt|2020}} |last=Kupferschmidt|first=Kai |date=20 December 2020 |title=Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear|url=https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear|url-status=live|archive-url=|archive-date=|access-date=21 December 2020 |website=[[Science (journal)|Science Mag]] |language=en}}</ref> inačica je [[SARS-CoV-2]], virusa koji uzrokuje [[COVID-19|koronavirusnu bolest 2019. (COVID-19)]].<ref name="NYT-20201221">{{cite news |last1=Zimmer |first1=Carel |last2=Carey |first2=Benedict |title=The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here’s what scientists know. |url=https://www.nytimes.com/2020/12/21/health/new-covid-strain-uk.html |date=21 December 2020 |work=[[The New York Times]] |accessdate=23 December 2020 }}</ref> Ova je varijanta prvi put otkrivena u [[Listopad|listopadu]] [[2020.]] godine tijekom [[Pandemija COVID-19|pandemije COVID-19]] u [[Velika Britanija|Ujedinjenom Kraljevstvu]] na uzorku uzetom prethodnog mjeseca,<ref name="BBC">{{Cite news |title=Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK |author= |website=BBC News |date=20 December 2020 |url= https://www.bbc.co.uk/news/world-europe-55385768}}</ref> i brzo se počela širiti do sredine prosinca. Koreliran je sa značajnim porastom stope infekcije COVID-19 u Ujedinjenom Kraljevstvu; Smatra se da je ovo povećanje barem djelomično zbog promjene N501Y unutar domene vezivanja za receptor glikoproteina, koja je potrebna za vezanje na ACE2 u ljudskim stanicama.
+'''Varijanta zabrinutosti 202012/01''' ('''VOC-202012/01'''),<ref>{{Citiranje weba |title=PHE investigating a novel strain of COVID-19 |author= |publisher=Public Health England |date=14 December 2020 |url= https://www.gov.uk/government/news/phe-investigating-a-novel-strain-of-covid-19}}</ref> prethodno poznata kao prva varijanta u istrazi u prosincu 2020. (''VUI - 202012/01''), a također i kao linija ''B. 1.1.7'',<ref name="Science Mag">{{Citiranje weba |ref={{sfnref|Kupferschmidt|2020}} |last=Kupferschmidt|first=Kai |date=20 December 2020 |title=Mutant coronavirus in the United Kingdom sets off alarms but its importance remains unclear|url=https://www.sciencemag.org/news/2020/12/mutant-coronavirus-united-kingdom-sets-alarms-its-importance-remains-unclear|url-status=live|archive-url=|archive-date=|access-date=21 December 2020 |website=[[Science (journal)|Science Mag]] |language=en}}</ref> inačica je [[SARS-CoV-2]], virusa koji uzrokuje [[COVID-19|koronavirusnu bolest 2019. (COVID-19)]].<ref name="NYT-20201221">{{cite news |last1=Zimmer |first1=Carel |last2=Carey |first2=Benedict |title=The U.K. Coronavirus Variant: What We Know = A newly identified variant of the SARS-CoV-2 virus appears to be more contagious than established ones. Here’s what scientists know. |url=https://www.nytimes.com/2020/12/21/health/new-covid-strain-uk.html |date=21 December 2020 |work=[[The New York Times]] |accessdate=23 December 2020 }}</ref> Ova je varijanta prvi put otkrivena u [[Listopad|listopadu]] [[2020.]] godine tijekom [[Pandemija COVID-19|pandemije COVID-19]] u [[Velika Britanija|Ujedinjenom Kraljevstvu]] na uzorku uzetom prethodnog mjeseca,<ref name="BBC">{{Cite news |title=Covid: Ireland, Italy, Belgium and Netherlands ban flights from UK |author= |website=BBC News |date=20 December 2020 |url= https://www.bbc.co.uk/news/world-europe-55385768}}</ref> i brzo se počela širiti do sredine prosinca. Koreliran je sa značajnim porastom stope infekcije COVID-19 u Ujedinjenom Kraljevstvu; Smatra se da je ovo povećanje barem djelomično zbog promjene N501Y unutar domene vezivanja za receptor glikoproteina, koja je potrebna za vezanje na ACE2 u ljudskim stanicama.
 == Otkriće ==