Nekodirajuća RNK: razlika između inačica

Posljednja izmjena od 20. ožujak 2022. u 08:12

Nekodirajuća RNK (eng. ncRNA) je sveobuhvatni naziv za ribonukleinske kiseline koje se ne prevode u bjelančevine kao glasnička RNK. U ove spadaju ribosomska RNK, prijenosna RNK, male RNK (miRNK, siRNK, piRNK, snRNK, snoRNK), lncRNK^[1], protusmislena RNK, riboprekidači i ribozim. Nekodirajuće RNK kod eukariota izrađuju najveći dio RNK koji nastaje prijepisom, kod ljudi oko 98%^[2] Imaju višestruke funkcije u stanici.^[3]

Literatura

J. S. Mattick, I. V. Makunin: Non-coding RNA. In: Human molecular genetics. Band 15 Spec No 1, April 2006, S. R17–R29, ISSN 0964-6906. doi: :10.1093/hmg/ddl046. PMID 16651366. (Review). PDF
F. F. Costa: Non-coding RNAs: lost in translation? In: Gene. Band 386, Nummer 1–2, Januar 2007, S. 1–10, ISSN 0378-1119. doi: :10.1016/j.gene.2006.09.028. PMID 17113247. (Review).

Vidi

nekodirajuća DNK

Izvori

↑ Derrien, T. et al.(2011): The Long Non-Coding RNAs: A New (P)layer in the "Dark Matter". In: Front Genet. 2:107. PMID 22303401 doi: 10.3389/fgene.2011.00107 PDF
↑ J. S. Mattick: Non-coding RNAs: the architects of eukaryotic complexity. In: EMBO reports. Band 2, Nummer 11, November 2001, S. 986–991, ISSN 1469-221X. doi: 10.1093/embo-reports/kve230. PMID 11713189. PMC:1084129 .
↑ G. Witzany: Noncoding RNAs: persistent viral agents as modular tools for cellular needs. In: Annals of the New York Academy of Sciences. Band 1178, Oktober 2009, S. 244–267, ISSN 1749-6632. doi: 10.1111/j.1749-6632.2009.04989.x. PMID 19845641.

[1] Derrien, T. et al.(2011): The Long Non-Coding RNAs: A New (P)layer in the "Dark Matter". In: Front Genet. 2:107. PMID 22303401 doi: 10.3389/fgene.2011.00107 PDF

[2] J. S. Mattick: Non-coding RNAs: the architects of eukaryotic complexity. In: EMBO reports. Band 2, Nummer 11, November 2001, S. 986–991, ISSN 1469-221X. doi: 10.1093/embo-reports/kve230. PMID 11713189. PMC:1084129 .

[3] G. Witzany: Noncoding RNAs: persistent viral agents as modular tools for cellular needs. In: Annals of the New York Academy of Sciences. Band 1178, Oktober 2009, S. 244–267, ISSN 1749-6632. doi: 10.1111/j.1749-6632.2009.04989.x. PMID 19845641.

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	~~<!--'''Nekodirajuća RNK'''-->'''~~Nekodirajuća RNK''' (eng. ncRNA) je sveobuhvatni naziv za ribonukleinske kiseline koje se ne [[translacija (biologija)\|prevode]] u [[bjelančevina\|bjelančevine]] kao [[glasnička RNK]]. U ove spadaju [[ribosomska RNK]], [[prijenosna RNK]], [[mala RNK\|male RNK]] ([[miRNK]], [[siRNK]], [[piRNK]], [[snRNK]], [[snoRNK]]), [[lncRNK]]<ref>Derrien, T. ''et al.''(2011): ''The Long Non-Coding RNAs: A New (P)layer in the "Dark Matter".'' In: ''Front Genet.'' 2:107. PMID 22303401 doi: [http://dx.doi.org/10.3389%2Ffgene.2011.00107 10.3389/fgene.2011.00107] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266617/pdf/fgene-02-00107.pdf PDF]</ref>, [[protusmislena RNK]], [[riboprekidač\|riboprekidači]] i [[ribozim]].		Nekodirajuća RNK''' (eng. ncRNA) je sveobuhvatni naziv za ribonukleinske kiseline koje se ne [[translacija (biologija)\|prevode]] u [[bjelančevina\|bjelančevine]] kao [[glasnička RNK]]. U ove spadaju [[ribosomska RNK]], [[prijenosna RNK]], [[mala RNK\|male RNK]] ([[miRNK]], [[siRNK]], [[piRNK]], [[snRNK]], [[snoRNK]]), [[lncRNK]]<ref>Derrien, T. ''et al.''(2011): ''The Long Non-Coding RNAs: A New (P)layer in the "Dark Matter".'' In: ''Front Genet.'' 2:107. PMID 22303401 doi: [http://dx.doi.org/10.3389%2Ffgene.2011.00107 10.3389/fgene.2011.00107] [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266617/pdf/fgene-02-00107.pdf PDF]</ref>, [[protusmislena RNK]], [[riboprekidač\|riboprekidači]] i [[ribozim]].
	Nekodirajuće RNK kod [[eukarioti\|eukariota]] izrađuju najveći dio [[RNK]] koji nastaje [[transkripcija (biologija)\|prijepisom]], kod ljudi oko 98%<ref>J. S. Mattick: ''Non-coding RNAs: the architects of eukaryotic complexity.'' In: ''EMBO reports.'' Band 2, Nummer 11, November 2001, S. 986–991, {{ISSN\|1469-221X}}. doi: [http://dx.doi.org/10.1093%2Fembo-reports%2Fkve230 10.1093/embo-reports/kve230]. PMID 11713189. {{PMC\|1084129}}.</ref> Imaju višestruke funkcije u stanici.<ref>G. Witzany: ''Noncoding RNAs: persistent viral agents as modular tools for cellular needs.'' In: ''Annals of the New York Academy of Sciences.'' Band 1178, Oktober 2009, S. 244–267, {{ISSN\|1749-6632}}. doi: [http://dx.doi.org/10.1111%2Fj.1749-6632.2009.04989.x 10.1111/j.1749-6632.2009.04989.x]. PMID 19845641.</ref>		Nekodirajuće RNK kod [[eukarioti\|eukariota]] izrađuju najveći dio [[RNK]] koji nastaje [[transkripcija (biologija)\|prijepisom]], kod ljudi oko 98%<ref>J. S. Mattick: ''Non-coding RNAs: the architects of eukaryotic complexity.'' In: ''EMBO reports.'' Band 2, Nummer 11, November 2001, S. 986–991, {{ISSN\|1469-221X}}. doi: [http://dx.doi.org/10.1093%2Fembo-reports%2Fkve230 10.1093/embo-reports/kve230]. PMID 11713189. {{PMC\|1084129}}.</ref> Imaju višestruke funkcije u stanici.<ref>G. Witzany: ''Noncoding RNAs: persistent viral agents as modular tools for cellular needs.'' In: ''Annals of the New York Academy of Sciences.'' Band 1178, Oktober 2009, S. 244–267, {{ISSN\|1749-6632}}. doi: [http://dx.doi.org/10.1111%2Fj.1749-6632.2009.04989.x 10.1111/j.1749-6632.2009.04989.x]. PMID 19845641.</ref>