Sarbecovirus - Povijest promjena

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2022-05-08T03:50:09Z

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	<!--'''Sarbecovirus'''-->[[~~File~~:SARS-CoV-2 virion animation.gif\|thumb\|400 px\|left\|[[SARS-CoV-2]] je primjer Sarbecovirus skupine (SARSr-CoV).]]		<!--'''Sarbecovirus'''-->[[Datoteka:SARS-CoV-2 virion animation.gif\|thumb\|400 px\|left\|[[SARS-CoV-2]] je primjer Sarbecovirus skupine (SARSr-CoV).]]

	'''Teški akutni respiratorni sindrom koronavirus (SARSr-CoV)''' ili '''Sarbecovirus''' je vrsta [[Coronaviridae\|koronavirusa]] sa spobnosću zaraze [[Osoba\|ljudi]], [[Šišmiš\|šišmiša]] i određene vrste [[Sisar\|sisara]]. To je omotani jednolančani [[RNK virus]] pozitivnog osjećaja koji ulazi u stanicu domaćina vezanjem na receptor enzima 2 ([[ACE2]]) za konverziju [[Angiotenzin\|angiotenzina]]. Član je roda [[Betacoronavirus]] i subgena '''Sarbecoronavirus'''.<ref name="ICTV10">{{Citiranje weba \|title=Virus Taxonomy: 2018 Release \|url=https://talk.ictvonline.org/taxonomy/ \|website=International Committee on Taxonomy of Viruses (ICTV) \|access-date=13 January 2019 \|language=en \|date=October 2018}}</ref><ref name=":02">{{cite journal \| vauthors = Woo PC, Huang Y, Lau SK, Yuen KY \| title = Coronavirus genomics and bioinformatics analysis \| journal = Viruses \| volume = 2 \| issue = 8 \| pages = 1804–20 \| date = August 2010 \| pmid = 21994708 \| pmc = 3185738 \| doi = 10.3390/v2081803 \| quote = Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein. }}</ref>		'''Teški akutni respiratorni sindrom koronavirus (SARSr-CoV)''' ili '''Sarbecovirus''' je vrsta [[Coronaviridae\|koronavirusa]] sa spobnosću zaraze [[Osoba\|ljudi]], [[Šišmiš\|šišmiša]] i određene vrste [[Sisar\|sisara]]. To je omotani jednolančani [[RNK virus]] pozitivnog osjećaja koji ulazi u stanicu domaćina vezanjem na receptor enzima 2 ([[ACE2]]) za konverziju [[Angiotenzin\|angiotenzina]]. Član je roda [[Betacoronavirus]] i subgena '''Sarbecoronavirus'''.<ref name="ICTV10">{{Citiranje weba \|title=Virus Taxonomy: 2018 Release \|url=https://talk.ictvonline.org/taxonomy/ \|website=International Committee on Taxonomy of Viruses (ICTV) \|access-date=13 January 2019 \|language=en \|date=October 2018}}</ref><ref name=":02">{{cite journal \| vauthors = Woo PC, Huang Y, Lau SK, Yuen KY \| title = Coronavirus genomics and bioinformatics analysis \| journal = Viruses \| volume = 2 \| issue = 8 \| pages = 1804–20 \| date = August 2010 \| pmid = 21994708 \| pmc = 3185738 \| doi = 10.3390/v2081803 \| quote = Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein. }}</ref>

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2022-01-02T20:50:42Z

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	== Morfologija ==		== Morfologija ==

	[[Morfologija]] [[Coronavirus\|koronavirusa]] povezanih sa [[SARS]] karakteristična je za obitelj [[Coronaviridae\|koronavirusa]] u cjelini. [[Virus\|Virusi]] su velike pleomorfne sferne čestice s bulbous površinskim izbočenjima koje tvore koronu oko čestica u elektronskim mikrografima. Veličina virusnih čestica je u rasponu od 80–90 nm. Ovojnica virusa u elektronskim mikrografima pojavljuje se kao poseban par elektronski gustih školjki.<ref>{{~~cite book~~ \| vauthors = Masters PS \| title = The molecular biology of coronaviruses \| volume = 66 \| pages = 193–292 \| date = 2006-01-01 \| pmid = 16877062 \| doi = 10.1016/S0065-3527(06)66005-3 \| publisher = Academic Press \| isbn = 9780120398690 \| quote = Nevertheless, the interaction between S protein and receptor remains the principal, if not sole, determinant of coronavirus host species range and tissue tropism. \| series = Advances in Virus Research }}</ref><ref>{{cite journal \| vauthors = Cui J, Li F, Shi ZL \| title = Origin and evolution of pathogenic coronaviruses \| journal = Nature Reviews. Microbiology \| volume = 17 \| issue = 3 \| pages = 181–192 \| date = March 2019 \| pmid = 30531947 \| doi = 10.1038/s41579-018-0118-9 \| pmc = 7097006 \| quote = Different SARS-CoV strains isolated from several hosts vary in their binding affinities for human ACE2 and consequently in their infectivity of human cells76,78 (Fig. 6b) }}</ref><ref>{{cite journal \| vauthors = Neuman BW, Adair BD, Yoshioka C, Quispe JD, Orca G, Kuhn P, Milligan RA, Yeager M, Buchmeier MJ \| display-authors = 6 \| title = Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy \| journal = Journal of Virology \| volume = 80 \| issue = 16 \| pages = 7918–28 \| date = August 2006 \| pmid = 16873249 \| pmc = 1563832 \| doi = 10.1128/JVI.00645-06 \| quote = Particle diameters ranged from 50 to 150 nm, excluding the spikes, with mean particle diameters of 82 to 94 nm; Also See Figure 1 for double shell. }}</ref>		[[Morfologija]] [[Coronavirus\|koronavirusa]] povezanih sa [[SARS]] karakteristična je za obitelj [[Coronaviridae\|koronavirusa]] u cjelini. [[Virus\|Virusi]] su velike pleomorfne sferne čestice s bulbous površinskim izbočenjima koje tvore koronu oko čestica u elektronskim mikrografima. Veličina virusnih čestica je u rasponu od 80–90 nm. Ovojnica virusa u elektronskim mikrografima pojavljuje se kao poseban par elektronski gustih školjki.<ref>{{Citiranje knjige \| vauthors = Masters PS \| title = The molecular biology of coronaviruses \| volume = 66 \| pages = 193–292 \| date = 2006-01-01 \| pmid = 16877062 \| doi = 10.1016/S0065-3527(06)66005-3 \| publisher = Academic Press \| isbn = 9780120398690 \| quote = Nevertheless, the interaction between S protein and receptor remains the principal, if not sole, determinant of coronavirus host species range and tissue tropism. \| series = Advances in Virus Research }}</ref><ref>{{cite journal \| vauthors = Cui J, Li F, Shi ZL \| title = Origin and evolution of pathogenic coronaviruses \| journal = Nature Reviews. Microbiology \| volume = 17 \| issue = 3 \| pages = 181–192 \| date = March 2019 \| pmid = 30531947 \| doi = 10.1038/s41579-018-0118-9 \| pmc = 7097006 \| quote = Different SARS-CoV strains isolated from several hosts vary in their binding affinities for human ACE2 and consequently in their infectivity of human cells76,78 (Fig. 6b) }}</ref><ref>{{cite journal \| vauthors = Neuman BW, Adair BD, Yoshioka C, Quispe JD, Orca G, Kuhn P, Milligan RA, Yeager M, Buchmeier MJ \| display-authors = 6 \| title = Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy \| journal = Journal of Virology \| volume = 80 \| issue = 16 \| pages = 7918–28 \| date = August 2006 \| pmid = 16873249 \| pmc = 1563832 \| doi = 10.1128/JVI.00645-06 \| quote = Particle diameters ranged from 50 to 150 nm, excluding the spikes, with mean particle diameters of 82 to 94 nm; Also See Figure 1 for double shell. }}</ref>

	Unutar ovojnice nalazi se nukleokapsid, koji je formiran od višestrukih kopija nukleokapsidnog (N) [[Protein\|proteina]], koji su vezani za jednolančani (približno 30 kb) genom RNK u neprekidnom [[RNK]] [[Genom\|genomu]] u kontinuiranom zrncu-na- struna tipa strune. Ovojnica lipidnog dvosloja, membranski proteini i [[Nukleokapsid\|nukleokapsid]] štite [[Virus\|virus]] kada je izvan domaćina.<ref>{{cite journal \| vauthors = Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ \| display-authors = 6 \| title = A structural analysis of M protein in coronavirus assembly and morphology \| journal = Journal of Structural Biology \| volume = 174 \| issue = 1 \| pages = 11–22 \| date = April 2011 \| pmid = 21130884 \| pmc = 4486061 \| doi = 10.1016/j.jsb.2010.11.021 \| quote = See Figure 10. }}</ref>		Unutar ovojnice nalazi se nukleokapsid, koji je formiran od višestrukih kopija nukleokapsidnog (N) [[Protein\|proteina]], koji su vezani za jednolančani (približno 30 kb) genom RNK u neprekidnom [[RNK]] [[Genom\|genomu]] u kontinuiranom zrncu-na- struna tipa strune. Ovojnica lipidnog dvosloja, membranski proteini i [[Nukleokapsid\|nukleokapsid]] štite [[Virus\|virus]] kada je izvan domaćina.<ref>{{cite journal \| vauthors = Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ \| display-authors = 6 \| title = A structural analysis of M protein in coronavirus assembly and morphology \| journal = Journal of Structural Biology \| volume = 174 \| issue = 1 \| pages = 11–22 \| date = April 2011 \| pmid = 21130884 \| pmc = 4486061 \| doi = 10.1016/j.jsb.2010.11.021 \| quote = See Figure 10. }}</ref>

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2021-12-09T20:20:45Z

Bot: Automatska zamjena teksta (-{{cite web +{{Citiranje weba)

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	<!--'''Sarbecovirus'''-->[[File:SARS-CoV-2 virion animation.gif\|thumb\|400 px\|left\|[[SARS-CoV-2]] je primjer Sarbecovirus skupine (SARSr-CoV).]]		<!--'''Sarbecovirus'''-->[[File:SARS-CoV-2 virion animation.gif\|thumb\|400 px\|left\|[[SARS-CoV-2]] je primjer Sarbecovirus skupine (SARSr-CoV).]]

	'''Teški akutni respiratorni sindrom koronavirus (SARSr-CoV)''' ili '''Sarbecovirus''' je vrsta [[Coronaviridae\|koronavirusa]] sa spobnosću zaraze [[Osoba\|ljudi]], [[Šišmiš\|šišmiša]] i određene vrste [[Sisar\|sisara]]. To je omotani jednolančani [[RNK virus]] pozitivnog osjećaja koji ulazi u stanicu domaćina vezanjem na receptor enzima 2 ([[ACE2]]) za konverziju [[Angiotenzin\|angiotenzina]]. Član je roda [[Betacoronavirus]] i subgena '''Sarbecoronavirus'''.<ref name="ICTV10">{{~~cite web~~ \|title=Virus Taxonomy: 2018 Release \|url=https://talk.ictvonline.org/taxonomy/ \|website=International Committee on Taxonomy of Viruses (ICTV) \|access-date=13 January 2019 \|language=en \|date=October 2018}}</ref><ref name=":02">{{cite journal \| vauthors = Woo PC, Huang Y, Lau SK, Yuen KY \| title = Coronavirus genomics and bioinformatics analysis \| journal = Viruses \| volume = 2 \| issue = 8 \| pages = 1804–20 \| date = August 2010 \| pmid = 21994708 \| pmc = 3185738 \| doi = 10.3390/v2081803 \| quote = Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein. }}</ref>		'''Teški akutni respiratorni sindrom koronavirus (SARSr-CoV)''' ili '''Sarbecovirus''' je vrsta [[Coronaviridae\|koronavirusa]] sa spobnosću zaraze [[Osoba\|ljudi]], [[Šišmiš\|šišmiša]] i određene vrste [[Sisar\|sisara]]. To je omotani jednolančani [[RNK virus]] pozitivnog osjećaja koji ulazi u stanicu domaćina vezanjem na receptor enzima 2 ([[ACE2]]) za konverziju [[Angiotenzin\|angiotenzina]]. Član je roda [[Betacoronavirus]] i subgena '''Sarbecoronavirus'''.<ref name="ICTV10">{{Citiranje weba \|title=Virus Taxonomy: 2018 Release \|url=https://talk.ictvonline.org/taxonomy/ \|website=International Committee on Taxonomy of Viruses (ICTV) \|access-date=13 January 2019 \|language=en \|date=October 2018}}</ref><ref name=":02">{{cite journal \| vauthors = Woo PC, Huang Y, Lau SK, Yuen KY \| title = Coronavirus genomics and bioinformatics analysis \| journal = Viruses \| volume = 2 \| issue = 8 \| pages = 1804–20 \| date = August 2010 \| pmid = 21994708 \| pmc = 3185738 \| doi = 10.3390/v2081803 \| quote = Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein. }}</ref>

	SARS coronavirus bio je jedan od nekoliko virusa koje je [[Svjetska zdravstvena organizacija]] (WHO) 2016. identificirala kao vjerojatni uzrok buduće epidemije u novom planu razvijenom nakon epidemije ebole za hitna istraživanja i razvoj prije i tijekom epidemije prema dijagnostici testovi, cjepiva i lijekovi. Predviđanje se obistinilo [[Pandemija COVID-19\|pandemijom koronavirusa 2019.-20.]]		SARS coronavirus bio je jedan od nekoliko virusa koje je [[Svjetska zdravstvena organizacija]] (WHO) 2016. identificirala kao vjerojatni uzrok buduće epidemije u novom planu razvijenom nakon epidemije ebole za hitna istraživanja i razvoj prije i tijekom epidemije prema dijagnostici testovi, cjepiva i lijekovi. Predviđanje se obistinilo [[Pandemija COVID-19\|pandemijom koronavirusa 2019.-20.]]
Redak 7:		Redak 7:
	== Porijeklo ==		== Porijeklo ==

	[[Šišmiš\|Šišmiši]] služe kao glavni rezervoar domaćina za koronavirus povezan sa SARS-om. [[Virus]] se koevoluirao u rezervoaru domaćina šišmiša tijekom dugog [[Vrijeme\|vremenskog]] razdoblja. Tek nedavno su evoluirali sojevi koronavirusa povezanih sa [[SARS]]-om i omogućili da vrsta vrsta preskoči sa slijepih miševa na ljude, kao u slučaju sojeva [[SARS-CoV]] i [[SARS-CoV-2]]. Oba ova soja potječu od jednog jedinog pretka, ali su križane vrste odvojeno skočile u ljude. [[SARS-CoV-2]] nije izravni potomak [[SARS-CoV]].<ref>{{cite journal \| vauthors = Woo PC, Huang Y, Lau SK, Yuen KY \| title = Coronavirus genomics and bioinformatics analysis \| journal = Viruses \| volume = 2 \| issue = 8 \| pages = 1804–20 \| date = August 2010 \| pmid = 21994708 \| pmc = 3185738 \| doi = 10.3390/v2081803 \| quote = Furthermore, subsequent phylogenetic analysis using both complete genome sequence and proteomic approaches, it was concluded that SARSr-CoV is probably an early split-off from the Betacoronavirus lineage [1]; See Figure 2. }}</ref><ref>{{~~cite web~~\|url=https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/223/coronaviridae-figures\|title=Coronaviridae - Figures - Positive Sense RNA Viruses - Positive Sense RNA Viruses (2011) \| work = International Committee on Taxonomy of Viruses (ICTV)\|language=en \|access-date=2020-03-06\|quote=See Figure 2.}}</ref>		[[Šišmiš\|Šišmiši]] služe kao glavni rezervoar domaćina za koronavirus povezan sa SARS-om. [[Virus]] se koevoluirao u rezervoaru domaćina šišmiša tijekom dugog [[Vrijeme\|vremenskog]] razdoblja. Tek nedavno su evoluirali sojevi koronavirusa povezanih sa [[SARS]]-om i omogućili da vrsta vrsta preskoči sa slijepih miševa na ljude, kao u slučaju sojeva [[SARS-CoV]] i [[SARS-CoV-2]]. Oba ova soja potječu od jednog jedinog pretka, ali su križane vrste odvojeno skočile u ljude. [[SARS-CoV-2]] nije izravni potomak [[SARS-CoV]].<ref>{{cite journal \| vauthors = Woo PC, Huang Y, Lau SK, Yuen KY \| title = Coronavirus genomics and bioinformatics analysis \| journal = Viruses \| volume = 2 \| issue = 8 \| pages = 1804–20 \| date = August 2010 \| pmid = 21994708 \| pmc = 3185738 \| doi = 10.3390/v2081803 \| quote = Furthermore, subsequent phylogenetic analysis using both complete genome sequence and proteomic approaches, it was concluded that SARSr-CoV is probably an early split-off from the Betacoronavirus lineage [1]; See Figure 2. }}</ref><ref>{{Citiranje weba\|url=https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/223/coronaviridae-figures\|title=Coronaviridae - Figures - Positive Sense RNA Viruses - Positive Sense RNA Viruses (2011) \| work = International Committee on Taxonomy of Viruses (ICTV)\|language=en \|access-date=2020-03-06\|quote=See Figure 2.}}</ref>

	== Morfologija ==		== Morfologija ==

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2021-12-09T08:04:42Z

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[[File:SARS-CoV-2 virion animation.gif|thumb|400 px|left|[[SARS-CoV-2]] je primjer Sarbecovirus skupine (SARSr-CoV).]]

'''Teški akutni respiratorni sindrom koronavirus (SARSr-CoV)''' ili '''Sarbecovirus''' je vrsta [[Coronaviridae|koronavirusa]] sa spobnosću zaraze [[Osoba|ljudi]], [[Šišmiš|šišmiša]] i određene vrste [[Sisar|sisara]]. To je omotani jednolančani [[RNK virus]] pozitivnog osjećaja koji ulazi u stanicu domaćina vezanjem na receptor enzima 2 ([[ACE2]]) za konverziju [[Angiotenzin|angiotenzina]]. Član je roda [[Betacoronavirus]] i subgena '''Sarbecoronavirus'''.<ref name="ICTV10">{{cite web |title=Virus Taxonomy: 2018 Release |url=https://talk.ictvonline.org/taxonomy/ |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=13 January 2019 |language=en |date=October 2018}}</ref><ref name=":02">{{cite journal | vauthors = Woo PC, Huang Y, Lau SK, Yuen KY | title = Coronavirus genomics and bioinformatics analysis | journal = Viruses | volume = 2 | issue = 8 | pages = 1804–20 | date = August 2010 | pmid = 21994708 | pmc = 3185738 | doi = 10.3390/v2081803 | quote = Figure 2. Phylogenetic analysis of RNA-dependent RNA polymerases (Pol) of coronaviruses with complete genome sequences available. The tree was constructed by the neighbor-joining method and rooted using Breda virus polyprotein. }}</ref>

SARS coronavirus bio je jedan od nekoliko virusa koje je [[Svjetska zdravstvena organizacija]] (WHO) 2016. identificirala kao vjerojatni uzrok buduće epidemije u novom planu razvijenom nakon epidemije ebole za hitna istraživanja i razvoj prije i tijekom epidemije prema dijagnostici testovi, cjepiva i lijekovi. Predviđanje se obistinilo [[Pandemija COVID-19|pandemijom koronavirusa 2019.-20.]]

== Porijeklo ==

[[Šišmiš|Šišmiši]] služe kao glavni rezervoar domaćina za koronavirus povezan sa SARS-om. [[Virus]] se koevoluirao u rezervoaru domaćina šišmiša tijekom dugog [[Vrijeme|vremenskog]] razdoblja. Tek nedavno su evoluirali sojevi koronavirusa povezanih sa [[SARS]]-om i omogućili da vrsta vrsta preskoči sa slijepih miševa na ljude, kao u slučaju sojeva [[SARS-CoV]] i [[SARS-CoV-2]]. Oba ova soja potječu od jednog jedinog pretka, ali su križane vrste odvojeno skočile u ljude. [[SARS-CoV-2]] nije izravni potomak [[SARS-CoV]].<ref>{{cite journal | vauthors = Woo PC, Huang Y, Lau SK, Yuen KY | title = Coronavirus genomics and bioinformatics analysis | journal = Viruses | volume = 2 | issue = 8 | pages = 1804–20 | date = August 2010 | pmid = 21994708 | pmc = 3185738 | doi = 10.3390/v2081803 | quote = Furthermore, subsequent phylogenetic analysis using both complete genome sequence and proteomic approaches, it was concluded that SARSr-CoV is probably an early split-off from the Betacoronavirus lineage [1]; See Figure 2. }}</ref><ref>{{cite web|url=https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/223/coronaviridae-figures|title=Coronaviridae - Figures - Positive Sense RNA Viruses - Positive Sense RNA Viruses (2011) | work = International Committee on Taxonomy of Viruses (ICTV)|language=en |access-date=2020-03-06|quote=See Figure 2.}}</ref>

== Morfologija ==

[[Morfologija]] [[Coronavirus|koronavirusa]] povezanih sa [[SARS]] karakteristična je za obitelj [[Coronaviridae|koronavirusa]] u cjelini. [[Virus|Virusi]] su velike pleomorfne sferne čestice s bulbous površinskim izbočenjima koje tvore koronu oko čestica u elektronskim mikrografima. Veličina virusnih čestica je u rasponu od 80–90 nm. Ovojnica virusa u elektronskim mikrografima pojavljuje se kao poseban par elektronski gustih školjki.<ref>{{cite book | vauthors = Masters PS | title = The molecular biology of coronaviruses | volume = 66 | pages = 193–292 | date = 2006-01-01 | pmid = 16877062 | doi = 10.1016/S0065-3527(06)66005-3 | publisher = Academic Press | isbn = 9780120398690 | quote = Nevertheless, the interaction between S protein and receptor remains the principal, if not sole, determinant of coronavirus host species range and tissue tropism. | series = Advances in Virus Research }}</ref><ref>{{cite journal | vauthors = Cui J, Li F, Shi ZL | title = Origin and evolution of pathogenic coronaviruses | journal = Nature Reviews. Microbiology | volume = 17 | issue = 3 | pages = 181–192 | date = March 2019 | pmid = 30531947 | doi = 10.1038/s41579-018-0118-9 | pmc = 7097006 | quote = Different SARS-CoV strains isolated from several hosts vary in their binding affinities for human ACE2 and consequently in their infectivity of human cells76,78 (Fig. 6b) }}</ref><ref>{{cite journal | vauthors = Neuman BW, Adair BD, Yoshioka C, Quispe JD, Orca G, Kuhn P, Milligan RA, Yeager M, Buchmeier MJ | display-authors = 6 | title = Supramolecular architecture of severe acute respiratory syndrome coronavirus revealed by electron cryomicroscopy | journal = Journal of Virology | volume = 80 | issue = 16 | pages = 7918–28 | date = August 2006 | pmid = 16873249 | pmc = 1563832 | doi = 10.1128/JVI.00645-06 | quote = Particle diameters ranged from 50 to 150 nm, excluding the spikes, with mean particle diameters of 82 to 94 nm; Also See Figure 1 for double shell. }}</ref>

Unutar ovojnice nalazi se nukleokapsid, koji je formiran od višestrukih kopija nukleokapsidnog (N) [[Protein|proteina]], koji su vezani za jednolančani (približno 30 kb) genom RNK u neprekidnom [[RNK]] [[Genom|genomu]] u kontinuiranom zrncu-na- struna tipa strune. Ovojnica lipidnog dvosloja, membranski proteini i [[Nukleokapsid|nukleokapsid]] štite [[Virus|virus]] kada je izvan domaćina.<ref>{{cite journal | vauthors = Neuman BW, Kiss G, Kunding AH, Bhella D, Baksh MF, Connelly S, Droese B, Klaus JP, Makino S, Sawicki SG, Siddell SG, Stamou DG, Wilson IA, Kuhn P, Buchmeier MJ | display-authors = 6 | title = A structural analysis of M protein in coronavirus assembly and morphology | journal = Journal of Structural Biology | volume = 174 | issue = 1 | pages = 11–22 | date = April 2011 | pmid = 21130884 | pmc = 4486061 | doi = 10.1016/j.jsb.2010.11.021 | quote = See Figure 10. }}</ref>

== Vidi još ==
* [[SARS-CoV]]
* [[SARS-CoV-2]]
* [[Betacoronavirus]]
* [[Coronaviridae]]

== Izvori ==
{{izvori}}

[[Kategorija:Koronavirus]]